Creatine and high-intensity performance: an energy source for maximum effort

May 30, 2026Michal Jetelina0 comments

Do you know that feeling when you are trying to give your absolute maximum? Whether it is a heavy set of squats, a maximum sprint on the track or an explosive take-off, at that moment your muscles are working flat out. These short but extremely demanding efforts require an enormous amount of energy in the shortest possible time. And this is exactly where creatine comes in.

Creatine and high-intensity performance – sprints and strength training

ATP: the universal currency of cellular energy

To carry out any muscle work, the body uses a single direct molecule: adenosine triphosphate, or ATP. It is the universal fuel for muscle contraction. The problem, though, is that the muscles keep only very small stores of ATP – in fact the existing stores will last you roughly just 2 seconds of maximum effort. If you want to carry on, the muscle cells have to start restoring ATP immediately.

The phosphocreatine energy system

Creatine occurs naturally in the body, with the largest stores (about 95 %) held in skeletal muscle. Fast-twitch muscle fibres (type II), responsible for explosive strength and sprints, contain more than 30 % more creatine than slow fibres. Most of this creatine is stored in the form of phosphocreatine (PCr). It is precisely this source of energy that is important for strength training, explosive movements and so on, as opposed to the anaerobic (breaking down carbohydrates into ATP without oxygen - e.g. a 1500 m run) or the aerobic energy system (breaking down carbohydrates and fats with oxygen - endurance running at submaximal intensity).

2 s
how long ATP stores last at maximum effort
5–20 s
time until phosphocreatine is used up in a sprint
+20 %
increase in creatine stores after supplementation

During high-intensity exercise (e.g. a 100 metre sprint) the level of phosphocreatine starts to fall immediately – it readily gives up its phosphate group to the broken-down ADP and, without needing oxygen, creates new ATP molecules. Most of the stores are used up within 5 to 20 seconds at maximum effort.

Phosphocreatine has one more biological advantage. The chemical reaction in which ATP is restored from phosphocreatine actively uses up the free hydrogen ions (H+) that arise during muscle work. This buffers the rapid acidification (acidosis) of the muscle and helps prevent premature failure of the contractile mechanism. Put simply – it delays the feeling of burning and fatigue, so the muscles hold their maximum strength for longer.

Why is a normal diet not enough?

Our body can produce a certain amount of creatine itself in the liver from amino acids and we take in another part from food – specifically from meat and fish. Strict vegetarians and vegans, however, have an almost zero intake of creatine from food. Even in people eating a normal diet the natural muscle stores are not filled to the absolute maximum – the muscles constantly lose roughly 2 grams of creatine a day, which is converted into creatinine and excreted in the urine.

Targeted supplementation can increase the total stores of creatine and phosphocreatine in the muscles by on average 20 %. In vegetarians with lower baseline values the increase can be even greater.

Specific benefits for performance

Research consistently shows that creatine supplementation demonstrably improves performance in both single and repeated sprints and in high-intensity exercise. The body is able to restore ATP sources faster during the short breaks between intervals, thanks to which you can manage more repetitions with a given weight during strength training.

An overview of the available literature shows that roughly 70 % of studies focused on sprints, strength training or interval work recorded a positive effect of creatine supplementation on strength, performance or force production (Greenhaff, Casey et al., 1993).

Balsom, Ekblom et al. (1993) – 6 days of supplementation with 25 g/day. In a test of 10 × 6-second sprints with 30-second breaks, the athletes taking creatine showed a smaller drop in performance across the repeated sprints than the placebo group.
Casey et al. (1996) – 5 days of supplementation with 20 g/day. During two 30-second cycling tests there was an increase in both maximum power and total work done. The improvement in performance was directly related to a higher concentration of phosphocreatine in the muscles.
Swimmers – In elite swimmers the effect on performance over 25–100 m was not clearly confirmed (Burke et al., 1996; Mujika et al., 1996; Peyrebrune et al., 1998). Some studies, however, did record a higher speed in repeated intervals (10 × 50 m, 8 × 45 m).
Other sports – Rossiter et al. (1996): improved performance of rowers over 1000 m. Chilibeck et al. (2007): in rugby players, a greater increase in repetitions in the bench press and leg press. Romer et al. (2001): in squash players, a lower level of fatigue in the closing phases of a match.
Creatine shows the greatest potential in activities characterised by repeated short bouts of high intensity. The size of its effect may be influenced by baseline creatine stores, the type of discipline or the level of training.

How should creatine be dosed?

If you want to maximise your muscle stores, you have two proven options:

Faster method
Loading protocol
Loading phase20 g / day
Splitting of doses4 × 5 g
Length of phase5–7 days
Maintenance dose2–3 g / day
Slower method
Gradual protocol
Continuous dose3 g / day
Full saturation~1 month
Final effectthe same
A tip for better absorption: Taking in carbohydrates stimulates the release of insulin, which supports the incorporation of creatine into the muscle cells. Taking creatine with a meal or drink rich in carbohydrates (roughly 100 g of carbohydrates per 5 g of creatine) can increase its absorption.

Conclusion for athletes

If your sport requires repeated explosiveness, lifting weights or lightning-fast sprints, creatine is an absolutely unbeatable supplement that will take your performance to a higher level.


References
  1. Greenhaff PL, Casey A, Short AH, et al. (1993). Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci, 84:565–571.
  2. Balsom PD, Ekblom B, Soderlund K, et al. (1993). Creatine supplementation and dynamic high-intensity intermittent exercise. Scand J Med Sci Sports, 3:143–149.
  3. Casey A, Constantin-Teodosiu D, Howell S, et al. (1996). Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol, 271(1):E31–E37.
  4. Burke LM, Pyne DB, Telford RD. (1996). Effect of oral creatine supplementation on single-effort sprint performance in elite swimmers. Int J Sport Nutr, 6(3):222–233.
  5. Mujika I, Chatard JC, Lacoste L, et al. (1996). Creatine supplementation does not improve sprint performance in competitive swimmers. Med Sci Sports Exerc, 28(11):1435–1441.
  6. Peyrebrune MC, Nevill ME, Donaldson FJ, Cosford DJ. (1998). The effects of oral creatine supplementation on performance in single and repeated sprint swimming. J Sports Sci, 16(3):271–279.
  7. Leenders NM, Lamb DR, Nelson TE. (1999). Creatine supplementation and swimming performance. Int J Sport Nutr, 9(3):251–262.
  8. Rossiter HB, Cannell ER, Jakeman PM. (1996). The effect of oral creatine supplementation on the 1000-m performance of competitive rowers. J Sports Sci, 14(2):175–179.
  9. Chilibeck PD, Magnus C, Anderson M. (2007). Effect of in-season creatine supplementation on body composition and performance in rugby union football players. Appl Physiol Nutr Metab, 32(6):1052–1057.
  10. Romer LM, Barrington JP, Jeukendrup AE. (2001). Effects of oral creatine supplementation on high intensity, intermittent exercise performance in competitive squash players. Int J Sports Med, 22(8):546–552.
  11. Jeukendrup A, Gleeson M. (2025). Sport nutrition (4th ed.). Human Kinetics.

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